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polymorphism studies

 

Identify polymorphs
Identifying polymorphic or amorphous forms of a compound can have a massive impact on the development of poorly soluble compounds. This is particularly true for poorly soluble compound, where the solubility can be dictated by the crystal form.

Overview of studies:

  • Miniaturized multiple crystallization experiments using evaporation and precipitation techniques, utilizing the most up to date software and hardware
  • State of the art characterization tools: Raman, X-ray powder diffraction and infrared spectroscopy, circular dichroism, differential scanning calorimetry, and microscopy
  • Evaluation of degree of solubility, crystallinity, chemical purity, hygroscopicity
  • Physical and chemical stability of polymorph or amorphous form in the dosage form
  • Rank-ordering of physical stability and suitability of the API from which final dosage forms are manufactured

Enhance solubility
The results of the Polymorphism Studies can also be invaluable in the identification of crystal forms that may enhance solubility.

 
 

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