Crystalline Technologies (oral & parenteral administration)

Survey, Speed and Icebreaker services use specific technologies to improve the solubility and dissolution of poorly soluble compounds. Classification of these technologies is based on the physical form of the compound and sub-categorized on how the desired form is obtained. In the Crystalline form, the molecules of the compound are organized in a structured and ordered low energy state. The physical structure needs to break up and the molecules have to go into solution before the compound can be absorbed in vivo.

Crystalline micronized particles produced by fracturing using conventional milling techniques. The powders possess a more uniform particle size and have an increased dissolution rate compared to coarse drug. To find out more about this technology click here.

Crystalline nanoparticles with a massive surface area produced by ball mill attrition. This increased surface area can further improve bioavailability compared to micronized material in cases where drug absorption is dissolution rate limited. To find out more about this technology click here.

Different crystal form generated with the appropriate type and ratio of counter ion. Selected for higher aqueous solubility giving rise to higher absorption than the free form.

Modified structure containing the drug co-crystallized with a complementary component. A satisfactory structure possesses a higher aqueous solubility or superior dissolution profile compared to the drug alone.